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Mark C Bowers, Texas A&M Univ, Temple, TX; Kurshed A Katki, Deborah B Kuck, Donald J DiPette, Scott& White Health System, Temple, TX; Scott C Supowit; Texas A&M Univ, Temple, TX Alpha-calcitonin gene-related peptide knockout -CGRP KO ; mice display a significant increase in basal blood pressure compared to their wild type WT ; counterparts. Initial observations from our laboratory demonstrated that aged 2 yr old ; -CGRP KO mice, fed a normal diet, were significantly heavier compared to WT controls 48.1 -3.4 vs 34.2 -1.8 gm ; . Therefore, the purpose of this study was to assess the role of -CGRP in obesity and insulin resistance in different age groups 10 12 weeks, 1 and 2 yrs old ; of -CGRP KO and WT mice. Adiponectin, a protein expressed in adipocytes that attenuates insulin resistance and obesity was significantly lower in the -CGRP KO compared to WT mice in the 3 different age groups 1 to 3 fold at 10 12 wks, 1 and 2 yrs old, respectively ; . Plasma glucose and insulin levels were significantly higher at all study ages in the -CGRP KO mice compared to their WT counterparts Plasma insulin levels ug L ; in the -CGRP KO mice were 0.64 -0.09 10 12 wks ; , 0.76 -0.1 1 yr ; , and 0.96 -0.12 2 yrs ; compared to 0.39 -0.08, 0.40 -0.06, and 0.59 -0.04 for WT mice, respectively. Glycated albumin, a marker for accelerated glycation of proteins resulting from elevated blood glucose levels, was also significantly higher in the -CGRP KO mice compared to WT controls at all ages studied -CGRP KO mice were 0.55 -0.02 mg ml 10 12 wks ; , 0.9 -0.07 mg ml 1 yr ; , and 1.3 -0.07 mg ml 2 yrs ; compared to 0.30 -0.05 mg ml, 0.34 -0.03 mg ml, and 0.42 -0.09 mg ml for WT mice, respectively ; . In addition, 60 minutes following an intraperitoneal insulin injection in 1 yr old mice, the -CGRP KO animals demonstrated a 2.5 fold decrease in glucose uptake compared to WT controls. These data demonstrate that similar to adrenomedullin, another member of the CGRP calcitonin gene family, -CGRP, a sensory neuropeptide, may play a significant role in mediating the components associated with the metabolic X syndrome, specifically hypertension, obesity, and insulin resistance, for example, periactin for appetite. Various Field Force initiatives were implemented to assist your Company to move forward and attain its objective of achieving global alignment by launching new products, and gaining leadership in the marketplace. The Pharmaceutical Field Force was restructured into three smaller therapy-focused teams, designed in a way to concentrate on target doctors in defined specialties, with products assigned in a manner that would help leverage their franchise and establish Pfizer's leadership in core therapy areas. An immediate offshoot of this transition was an increase in Field Force productivity and the consequent strong growths achieved by key products. Information technology was leveraged through OPTIMA II the online web enabled Field Force reporting and work scheduling system, coupled with OPTILEARN - the e-learning module, to augment the selling capabilities and improve the effectiveness of your Company's sales force. A new software program MEDICO for order processing was implemented at thirty-five CFA locations and three warehouses across the country. Modernization of this Inventory Control System will enable all stakeholders in the sales operation to analyze data and make informed decisions, thus enhancing the efficiency of the entire distribution chain and propranolol.

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